Exploring history pertinent to evolutionary developmental biology (hereafter, Evo-devo) is an exciting prospect given its current status as a cutting-edge field of research. The first and obvious question concerns where to begin searching for materials and sources. Since this new discipline adopts a moniker that intentionally juxtaposes ‘evolution’ and development’, individuals, disciplines, and institutional contexts relevant to the history of evolutionary studies and investigations of ontogeny prompt themselves. Each of these topics has received attention from historians and thus there is (...) both primary and secondary material from which to draw. For example, many historians have documented the historical trajectories of genetics and embryology, their split, and various relations (or lack thereof), especially in the first three decades of the 20th century. (shrink)

'Updating Bertrand Russell for the 21st century... a cerebrally enjoyable survey, written with great clarity and touches of wit... The non-western section throws up some fascinating revelations' Sunday Times The story of philosophy is an epic tale: an exploration of the ideas, views and teachings of some of the most creative minds known to humanity. But since the long-popular classic Bertrand Russell's History of Western Philosophy, first published in 1945, there has been no comprehensive and entertaining, single-volume history of this (...) great intellectual journey. With his characteristic clarity and elegance A. C. Grayling takes the reader from the world-views and moralities before the age of the Buddha, Confucius and Socrates, through Christianity's dominance of the European mind to the Renaissance and Enlightenment, and on to Mill, Nietzsche, Sartre, and philosophy today. And, since the story of philosophy is incomplete without mention of the great philosophical traditions of India, China and the Persian-Arabic world, he gives a comparative survey of them too. Intelligible for students and eye-opening for philosophy readers, he covers epistemology, metaphysics, ethics, aesthetics, logic, the philosophy of mind, the philosophy of language, political philosophy and the history of debates in these areas of enquiry, through the ideas of the celebrated philosophers as well as less well-known influential thinkers. He also asks what we have learnt from this body of thought, and what progress is still to be made. The first authoritative and accessible single-volume history of philosophy for decades, remarkable for its range and clarity, this is a landmark work. (shrink)

The larval arms of echinoid plutei are used for locomotion and feeding. They are composed of internal calcite skeletal rods covered by an ectoderm layer bearing a ciliary band. Skeletogenesis includes an autonomous molecular differentiation program in primary mesenchyme cells (PMCs), initiated when PMCs leave the vegetal plate for the blastocoel, and a patterning of the differentiated skeletal units that requires molecular cues from the overlaying ectoderm. The arms represent a larval feature that arose in the echinoid lineage during the (...) Paleozoic and offers a subject for the study of gene co-option in the evolution of novel larval features. We isolated new molecular markers in two closely related but differently developing species, Heliocidaris tuberculata and Heliocidaris erythrogramma. We report the expression of a larval arm-associated ectoderm gene tetraspanin, as well as two new PMC markers, advillin and carbonic anhydrase. Tetraspanin localizes to the animal half of blastula stage H. tuberculata and then undergoes a restriction into the putative oral ectoderm and future location of the postoral arms, where it continues to be expressed at the leading edge of both the postoral and anterolateral arms. In H. erythrogramma, its expression initiates in the animal half of blastulae and expands over the entire ectoderm from gastrulation onward. Advillin and carbonic anhydrase are upregulated in the PMCs postgastrulation and localized to the leading edge of the growing larval arms of H. tuberculata but do not exhibit coordinated expression in H. erythrogramma larvae. The tight spatiotemporal regulation of these genes in H. tuberculata along with other ontogenetic and phylogenetic evidence suggest that pluteus arms are novel larval organs, distinguishable from the processes of skeletogenesis per se. The dissociation of expression control in H. erythrogramma suggest that coordinate gene expression in H. tuberculata evolved as part of the evolution of pluteus arms, and is not required for larval or adult development. (shrink)

Although sciences are often conceptualized in terms of theory confirmation and hypothesis testing, an equally important dimension of scientific reasoning is the structure of problems that guide inquiry. This problem structure is evident in several concepts central to evolutionary developmental biology (Evo-devo)—constraints, modularity, evolvability, and novelty. Because problems play an important role in biological practice, they should be included in biological pedagogy, especially when treating the issue of scientific controversy. A key feature of resolving controversy is synthesizing methodologies from different (...) biological disciplines to generate empirically adequate explanations. Concentrating on problem structure illuminates this interdisciplinarity in a way that is often ignored when science is taught only from the perspective of theory or hypothesis. These philosophical considerations can assist life science educators in their continuing quest to teach biology to the next generation. -/- . (shrink)

The core of the third chapter is the study of the P‐series. This theory is presented after a detailed discussion of the relationship of individuals to species and genus. A P‐series is a sequence of terms classified according to priority and posteriority starting from the most universal one. This theory is the result of the evolution of the Aristotelian doctrine of pros en done in order to fit with the not strictly Aristotelian notion of ‘genus’ of some Neoplatonic philosophers.

An overlooked feature of Darwin’s work is his use of “imaginary illustrations” to show that natural selection is competent to produce adaptive, evolutionary change. When set in the context of Darwin’s methodology, these thought.

Judgments of plausibility involve appearance of the truth or reasonableness, which is always a function of background knowledge. What anyone will countenance is conditioned by what they already know (or think they know). Marc Kirschner (professor of systems biology at Harvard) and John Gerhart (professor of molecular and cell biology at the University of California—Berkeley) aim to show that molecular, cellular, and developmental processes relevant to the generation of phenotypic variation in anatomy, physiology, and behavior demonstrate how evolutionary processes, especially (...) the origins of novelty, are plausible. The outstanding question for Kirschner and Gerhart concerns not the modification of structures but their origination—a question unanswered by the theoretical framework of the modern synthesis. (shrink)